| # | Team | Pick |
| 1 | | Detroit Lions
(0-16) | Andre Smith, OT, Alabama. |
| 2 | | St. Louis Rams
(2-14) | Eugene Monroe, OT, Virginia |
| 3 | | Kansas City Chiefs
(2-14) | Aaron Curry, OLB, Wake Forest |
| 4 | | Seattle Seahawks
(4-12) | Micheal Crabtree, WR, Texas Tech |
| 5 | | Cleveland Browns
(4-12) | Malcolm Jenkins, CB, Ohio St. |
| 6 | | Cincinnati Bengals
(4-11-1) | Jason Smith, OT, Baylor |
| 7 | | Oakland Raiders
(5-11) | Jeremy Maclin, WR, Missouri. |
| 8 | | Jacksonville Jaguars
(5-11) | B.J. Raji, DT, Boston College. |
| 9 | | Green Bay Packers
(6-10) | Brian Orakpo, DE, Texas. |
| 10 | | San Francisco 49ers
(7-9) | Matt Stafford, QB, Georgia. |
| 11 | | Buffalo Bills
(7-9) | Brandon Pettigrew, TE, Oklahoma St. |
| 12 | | Denver Broncos
(8-8) | William Moore, S, Missouri. |
| 13 | | Washington Redskins
(8-8) | Rey Maualuga, ILB, Ohio St. |
| 14 | | New Orleans Saints
(8-8) | Everette Brown, DE/OLB, Florida St. |
| 15 | | Houston Texans
(8-8) | Vontae Davis, CB, Illinois |
| 16 | | San Diego Chargers
(8-8) | James Lauranitis, ILB, Ohio St. |
| 17 | | New York Jets
(9-7) | Micheal Oher, OT, Ole Miss |
| 18 | | Chicago Bears
(9-7) | Darius Heyward-Bey, WR, Maryland |
| 19 | | Tampa Bay Buccaneers
(9-7) | Tyson Jackson, DE, LSU |
| 20 | | Detroit Lions
(9-7, Pick via Cowboys) | Mark Sanchez, QB, USC |
| 21 | | Philadelphia Eagles
(9-6-1) | Chris “Beanie” Wells, RB, Ohio St. |
| 22 | | Minnesota Vikings
(10-6) | Percy Harvin, WR, Florida |
| 23 | | New England Patriots
(11-6) | LeSean McCoy, RB, Pittsburgh |
| 24 | | Atlanta Falcons
(11-5) | Eben Britton, OT, Arizona |
| 25 | | Miami Dolphins
(11-5) | Clint Sintim, OLB, Virginia |
| 26 | | Baltimore Ravens
(11-5) | D.J. Moore, CB, Vanderbilt-With McAllister almost definitely leaving, the Ravens need a corner to go along with Fabian Washington, and Samari Rolle is at the end of his road. Moore is a ball-hawk, grabbing a pick per 2 games for the last two seasons. He has ok size, 5’10”, but is very physical and talented. |
| 27 | | Indianapolis Colts
12-4) | Duke Robinson, G, Oklahoma. |
| 28 | | Philadelphia Eagles
(12-4; Pick via CAR) | Darry Beckwith, ILB, LSU |
| 29 | | New York Giants
(12-4) | Brian Cushing, OLB, USC |
| 30 | | Tennessee Titans
(13-3) | Kenny Britt, WR, Rutgers |
| 31 | | Arizona Cardinals
(9-7) | Peria Jerry, DT, Ole Miss |
| 32 | | Pittsburgh Steelers
(12-4) | Alex Mack, C, Cal |
