| # | Team | Pick |
| 1 | | Detroit Lions (0-16) | Matt Stafford, QB, Georgia |
| 2 | | St. Louis Rams (2-14) | Jason Smith, OT, Baylor |
| 3 | | Kansas City Chiefs (2-14) | Aaron Curry, OLB, Wake Forest |
| 4 | | Seattle Seahawks (4-12) | Michael Crabtree, WR, Texas Tech |
| 5 | | Cleveland Browns (4-12) | Brian Orakpo, DE/OLB, Texas |
| 6 | | Cincinnati Bengals (4-11-1) | Eugene Monroe, OT, Virginia |
| 7 | | Oakland Raiders (5-11) | Jeremy Maclin, WR, Missouri. |
| 8 | | Jacksonville Jaguars (5-11) | B.J. Raji, DT, Boston College |
| 9 | | Green Bay Packers (6-10) | Everette Brown, DE/OLB, Florida St. |
| 10 | | San Francisco 49ers (7-9) | Mark Sanchez, QB, USC |
| 11 | | Buffalo Bills (7-9) | Aaron Maybin, DE, Penn State |
| 12 | | Denver Broncos (8-8) | Tyson Jackson, DE, LSU |
| 13 | | Washington Redskins (8-8) | Michael Oher, OT, Ole Miss |
| 14 | | New Orleans Saints (8-8) | Malcolm Jenkins, CB/FS, Ohio State |
| 15 | | Houston Texans (8-8) | Clay Matthews, OLB, USC |
| 16 | | San Diego Chargers (8-8) | Andre Smith, OT, Alabama. |
| 17 | | New York Jets (9-7) | Chris Wells, RB, Ohio State |
| 18 | | Denver Broncos (Via Chicago) | Brian Cushing, OLB, USC |
| 19 | | Tampa Bay Buccaneers (9-7) | Josh Freeman, QB, Kansas State |
| 20 | | Detroit Lions (9-7, Pick via Cowboys) | William Beatty, OT, UConn |
| 21 | | Philadelphia Eagles (9-6-1) | Brandon Pettigrew, TE, Ohio State |
| 22 | | Minnesota Vikings (10-6) | Vontae Davis, CB, Illinois |
| 23 | | New England Patriots (11-6) | Rey Maualuga, ILB, USC |
| 24 | | Atlanta Falcons (11-5) | James Lauranitis, ILB, Ohio State |
| 25 | | Miami Dolphins (11-5) | Darius Butler, CB, UConn |
| 26 | | Baltimore Ravens (11-5) | Darius Heyward-Bey, WR, Maryland: I really think it is realistic that he could fall here. |
| 27 | | Indianapolis Colts 12-4) | Peria Jerry, DT, Ole Miss |
| 28 | | Philadelphia Eagles (12-4; Pick via CAR) | William Moore, S, Missouri |
| 29 | | New York Giants (12-4) | Kenny Britt, WR, Rutgers |
| 30 | | Tennessee Titans (13-3) | Percy Harvin, WR, Florida |
| 31 | | Arizona Cardinals (9-7) | Knowshown Moreno, RB, Georgia |
| 32 | | Pittsburgh Stinkers (12-4) | Alex Mack, C, California |
